- Sleepy medicine, sleepy mist and awakening mist arrived at Sakuma Corp in version 1.042.10 on April 17, 2024.
- Garusoft states in the release notes that all three have no effect on enemies.
- The notes list no price, duration or range, so those details have to be checked in the game.
- A separate item, Small Mist, once left the tax manager upside down and buried in the floor before a December 2024 fix.
- Official Google Play material says enemies can be beaten without weapons by inducing self destruction or their own attacks.
You buy sleepy medicine in Sakura School Simulator, use it on an enemy, and nothing happens. That is not a bug, because Garusoft says outright that the item has no effect on enemies.
We went through the game's App Store version history and its official Google Play material to see what is actually on record about these items. The record is short, and that matters: plenty of the details passed around by players have no basis in the official notes.
This guide separates what the developer has confirmed from what you will need to test yourself.
Quick answer: Sleepy medicine, sleepy mist and awakening mist have been available at Sakuma Corp since version 1.042.10 (April 17, 2024). Garusoft says all three have no effect on enemies, so they will not win you a fight. For enemies, the game's official material points to another approach: inducing their self destruction or their own attacks.What the Official Release Notes Say
The three items appear in the App Store notes for version 1.042.10, dated April 17, 2024. The entry is a single sentence: Sleepy medicine, sleepy mist, and awakening mist (No effect on enemies) in Sakuma Corp.
That sentence settles three things. There are three items, they are found at Sakuma Corp, and they do not work on enemies. The note in brackets comes from the developer, so the restriction is deliberate.
The same update carried a lot of other content, which makes these items easy to miss. The table below sums it up.
| In version 1.042.10 | Details |
|---|---|
| Sleepy medicine, sleepy mist, awakening mist | At Sakuma Corp, no effect on enemies |
| Ramen shop | Open from 10:00 to 23:00 |
| Ramen and gyoza | Added as props and in item edit (table category) |
| Vehicles | Two cars at the car shop, a camper at the campsite |
| Pose mode | New NPC "turn the body" option rotates the upper body toward the camera or player |
| Appearance | 2 female and 3 male hairstyles, hats, changeable hair ribbon color |
Table source: App Store release notes for version 1.042.10.
Sleepy Medicine vs Sleepy Mist vs Awakening Mist
Garusoft does not explain how each item works, so the distinctions here come from the names alone. Going by those names, the first two are meant to put someone to sleep, and the third does the opposite.
How the medicine differs from the mist, for example whether the mist reaches a wider area, is not explained in any release note we read.
The same goes for price, duration and range. If a guide quotes a specific number, compare it with the in-game shop screen first, since that screen is the safest reference for the version you are playing.
If Enemies Are Immune, How Do You Deal With Them?
Since sleepy medicine will not help, you need another plan once a fight starts. The game's Google Play description mentions battle-style missions, and it says weapons are not lying around on the ground: you borrow them from a suspicious office.
One of the official Google Play screenshots offers a more interesting hint. Its caption reads: You need no weapons by inducing enemy's self destruction or enemy's attack.
So the approach is about positioning, not about disabling enemies. Draw their attacks somewhere that works in your favor, then get clear before anything explodes. Press SAVE before you try it so you can restart from a safe point.
Small Mist and the Tax Manager Bug
Mist items have also produced one of the game's funnier bugs. The notes for version 1.043.21, dated December 20, 2024, say that using Small Mist on the tax manager could leave him upside down and buried in the floor.
That bug has been fixed. In the App Store history we could read, 25 versions from May 2023 to September 2026, these are the only two entries that clearly mention mist items. None of them changes the rule about enemies, although that history does not cover the newest Android builds.
The current Google Play version is 1.048.19. Its notes cover a fix for transparent school stairs, plus the Sun setting added in 1.048.18, with no mention of medicine or mist.
How to Test the Items and Use Them in Stories
To find out the exact effect on your own device, run a simple test. Save first, buy one item, and try it on a single ordinary character in a quiet spot. Note how long the effect lasts, then repeat with awakening mist.
Once you know the result, these items are more useful for content than for combat. Think of a scene where a student dozes off in class and a friend wakes them up, or a comedy sketch where a whole town gets drowsy. The pose mode option from the same update helps, because NPCs can turn toward the camera.
Keep in mind that these are fictional game items. Giving someone sleep medication without a prescription and their consent is dangerous in real life, so never copy this, even as a joke for content.
FAQ (Frequently Asked Questions)
According to the notes for version 1.042.10, sleepy medicine, sleepy mist and awakening mist are available at Sakuma Corp. It is designed that way. Garusoft wrote No effect on enemies in the release notes, so it is not a bug. The official release notes do not list a price. Check the in-game shop so the figure matches the version you are playing. Garusoft does not spell it out. The name suggests the opposite of sleepy mist, and the exact effect is best confirmed in the game. An official Google Play screenshot says you need no weapons if you induce an enemy's self destruction or an enemy's attack.1. Where can I buy sleepy medicine in Sakura School Simulator?
2. Why doesn't sleepy medicine work on enemies?
3. How much does sleepy medicine cost?
4. What does awakening mist do?
5. How do you beat enemies without weapons?
Conclusion
The sleepy items at Sakuma Corp are not a secret weapon. The developer has already said they have no effect on enemies, so do not spend in-game money on them for that purpose.
Their value lies in interactions and storytelling. If you want to win fights, practice drawing enemy attacks instead, as the game's official material shows.
- All three items arrived in version 1.042.10 on April 17, 2024.
- They are found at Sakuma Corp and have no effect on enemies.
- Price, duration and range are not in the release notes.
- Handle enemies by inducing their self destruction or their own attacks.
- These are fictional items, so never copy them in real life.
